To create a 2D isometric game character rig similar to the one shown in the video you mentioned, you can follow the guidance provided in the Spine forums and resources. For isometric characters, it's common to have animations seen from different angles, and you might need to mirror animations at runtime or within Spine by scaling a parent bone to -1 on one axis to achieve the desired effect. The process involves rearranging assets and the draw order to make your character face different directions. You can reuse parts of animations, like body movements, but may need to adjust others, like the feet in a walk cycle, to match the new perspective.
For a comprehensive guide, the Spine Twitch page offers downloadable projects and videos detailing complete rigging processes, including isometric characters. One specific series mentioned in the forums is about creating an isometric character walking in 8 directions, which includes a downloadable project and a complete rigging process. This resource can be particularly helpful for understanding how to rig and animate your character for an isometric game.
Here are some resources to get you started:
Remember, the complexity of your character's skeleton and animations will depend on the design and the actions you want to achieve. Planning your character and animations ahead can help streamline the rigging and animation process.