For a game engine that handles Spine 4.2 easily and cleanly, you might want to consider using PixiJS or Phaser. Both of these game engines have strong integrations with Spine and are designed to make rendering and manipulating Spine animations straightforward.
PixiJS: This is a 2D rendering engine that works well with Spine. It provides a simple API for rendering Spine animations and is known for its performance and ease of use. You can find more information and examples on how to use PixiJS with Spine here.
Phaser: This is a popular HTML5 game framework that also has good support for Spine animations. Phaser's integration with Spine allows you to easily load and play Spine animations, and it provides a lot of flexibility for game development. More details on using Phaser with Spine can be found here.
Both of these engines are well-suited for handling Spine animations and provide a relatively easy setup for game development. They also offer good documentation and community support, which can be very helpful as you develop your game.